Zephyr® Endobronchial Valve

The Zephyr® Endobronchial Valve is an endoscopic lung volume reduction therapy that has been proven to significantly improve lung function, exercise capacity and quality of life for emphysema patients across four randomized, controlled clinical trials and in 25,000 patients worldwide.

In combination with its diagnostic companion products, it uniquely offers a prospectively proven method for predicting responders. It is also designed to be removable, preserving future treatment options for patients.

The UK’s National Institute for Health and Care Excellence (NICE) has updated its guidance for endobronchial valves and now considers current evidence sufficient to support routine use. The change in NICE guidance is based on safety and efficacy data from multiple randomized clinical trials evaluating the Zephyr EBV, which has demonstrated clinical and quality of life benefits, and long-term safety for eligible patients.

With the valves, we can treat patients who did not have any treatment options before.

Dr. med. Dirk-Jan Slebos,
PhD – UMC Groningen – The Netherlands

This is one of the best technologies for our end stage patient.

Prof. Dr. med. Felix Herth,
FCCP – UniversitätsKlinikum Heidelberg – Germany

In the right patient, the Zephyr is always going to be my first choice.

Dr. Pallav Shah,
MD – Royal Brompton & Harefield London – United Kingdom

How it works

Using a standard bronchoscope, Zephyr Valves are delivered to target airways using a flexible delivery catheter
Once implanted, the tiny valve prevents airflow into the diseased region, while allowing trapped air to escape
Reducing the volume of the diseased region may allow healthier regions to expand and function more efficiently

The Zephyr endobronchial delivery catheter enables efficient and controlled delivery of the Zephyr Valve

  • Proper valve sizing: The diameter gauges allow for a quick visual measurement of the bronchial diameter
  • Accurate positioning: A depth marker assists in positioning the catheter prior to valve deployment placement
  • Controlled delivery: An actuator lever facilitates precise deployment of the valve
Zephyr Endobronchial Valve
Item number Description Airway diameter range
EBV-TS-4.0 Zephyr 4.0 Endobronchial Valve 4.0–7.0 mm
EBV-TS-4.0-LP Zephyr 4.0-LP Endobronchial Valve 4.0–7.0 mm
EBV-TS-5.5 Zephyr 5.5 Endobronchial Valve 5.5–8.5 mm
Zephyr Delivery Catheter
Item number Description
EDC-TS-4.0 Zephyr 4.0 Endobronchial Delivery Catheter
EDC-TS-4.0-J Zephyr 4.0-J Endobronchial Delivery Catheter
EDC-TS-5.5 Zephyr 5.5 Endobronchial Delivery Catheter

Note: Each Catheter can be used to deploy up to four valves per patient


Complications of the Zephyr Endobronchial Valve treatment can include but are not limited to pneumothorax, worsening of COPD symptoms, haemoptysis, pneumonia, dyspnoea and, in rare cases, death.